Multiwalled polyurethane–polyurea nanoparticles

Multiwalled polyurethane–polyurea nanoparticles desde Ecopol Tech SL

Por: Ecopol Tech SL  07/10/2015
Palabras clave: Architecture, Polyurea, encapsulation

Polyurethane–polyurea (PUUa) reactive prepolymers with adjusted hydrophobic and hydrophilic dangling chains to achieve multiwalled sub-30 nm nanoparticles are presented. The combination of an amphiphilic and a hydrophobic prepolymer at the oil–water interface creates a stratified shell by hydrophobic interactions. These novel nanostructures enhance the encapsulation stability of lipophilic compounds compared to monowalled nanostructures and facilitate the selective and ordered functionalization along the multiwalled shell with bioactive motifs. As proof of concept, PUUa nanoparticles have been engineered with disulfide bonds and an αvβ3 integrin-selective cyclic RGD peptide (cRGDfK) providing our system with glutathione (GSH) triggered controlled release and cell targeting specificity to U87 tumor cells.

Palabras clave: amphiphilia, amphiphilic polymer, Architecture, bioconjugation, cancer treatment, encapsulation, hydrophobia, hydrophobic effect, monowalled, multiwalled, nanostructure, Polyurea, prepolymer, RGD peptide, self-assembly, stratification, triggered release,

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